Mesothelioma Prevention And Precaution
In my earlier article pertaining to “mesothelioma and asbestos side effects”, I have briefly discussed on the possible side effects common folks maybe faced with should they have any form of furniture or asset fittings within their occupied premise (both at home as well as your workplace) that are made essentially from materials comprising of asbestos components or elements. It was highlighted that workers engaged in certain industries or trade handling or working with asbestos materials should be adequately protected. Specifically, what level of protection as well as precaution should be undertaken? First off, let’s look at the work environment you are currently at: Is it adequately ventilated either through natural ventilation (as in a workplace with generous amount of window openings) or mechanical ventilation (as in is your workplace air-conditioned or provided with other means of positive pressure ventilation)? Are your work stations well spaced out? Is the machinery used by each staff well spaced out as well? Your work environment needs to be properly assessed as it will further determine the level of personal protection you’ll need to provide for your staff or self provided (depending whether you’re working in a large organization or whether you’re self employed). A work environment which has work stations located too close to one another, is in a stuffy and hot room, or situated in a humid country will affect how asbestos particles when released into the environment will propagate. As far as possible, a well balanced form of workplace ventilation should be practiced. While air-conditioning the whole workplace maybe costly in the long run and thus not feasible in terms of monthly electrical bills, this form of balance can be maintained with suitable window openings properly planned out with your contractor or space planner. Going further, the choice of lighting also plays a part in the influencing the room temperature. Too many lights that are not well spaced out? Well, you get the picture. The rate of release of asbestos particles is not only dependent on the environmental temperature, but is also dependent on the level of work being exercised upon. By this, we’re referring to the rate of production of such asbestos components (such as gypsum board manufacturing, etc.). While it may not be a wise business decision to slow down the rate of production in the name of workplace safety and health (then again, it depends on who and where you’re working for), the provision of suitable personal protective equipment (or PPE) shall come into play. At the minimal level, a proper individually-fitted N95 level face mask along with goggles should be provided for the upper chest level, followed by proper safety

Dangerous Dust
What would you do if you found out that the roads you drive on could cause cancer? This is the reality that residents face in Dunn County, North Dakota. For roughly 30 years, gravel containing the potentially carcinogenic mineral erionite was spread on nearly 500 kilometers of roads, playgrounds, parking lots, and even flower beds throughout Dunn County... (Source: Health News from Medical News Today)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.januarysales.org/" target="_blank">January Sales</a> in the UK.</p></div>
Week In Review at Mesothelioma Center: Asbestos Activists Working, Libby Victims Getting Help
It was a busy week at the Mesothelioma Center with anti-asbestos activists in Canada finding success, victims in Libby getting some much-needed help, and residents in Vermont debating a Superfund site. (Source: Asbestos and Mesothelioma News)
White House Criticized about Workplace Policies of Toxins Like Asbestos
The White House received criticism for delaying a regulation that provides a safer work environment against toxins like asbestos, citing that approximately 60 lives could have been saved during the time that the policy was being held up. (Source: Asbestos and Mesothelioma News)
Asbestos in Schools ?A National Scandal? in United Kingdom
Asbestos contamination in schools throughout the United Kingdom has become "a national scandal,'' according to one Member of Parliament who has asked for swift action to correct the growing health concern. (Source: Asbestos and Mesothelioma News)
Vermont Residents Debate Whether Asbestos Mine Should Become Superfund Site
Vermont residents are debating whether the Belvidere Mountain Asbestos mine should become a Superfund site. If the mine is cleaned up through the EPA program, a biomass electric generation plant will be added in its place. (Source: Asbestos and Mesothelioma News)
Malignant biphasic peritoneal mesothelioma in a child: Consideration of other diagnostic possibilities
(Source: Diagnostic Cytopathology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Please support the <a href="http://www.doctorsinchains.org/" target="_blank">Doctors In Chains</a> campaign for the <a href="http://www.doctorsinchains.org/">medics</a> tortured and sentenced for up to 15 years in <a href="http://www.doctorsinchains.org/">Bahrain</a>. <a href="https://twitter.com/#!/search/%23FreeDoctors">#FreeDoctors</a></p></div>
Asbestos Victims in Libby Finally Seeing Settlement with Montana
More than a decade after originally filing suit against the state of Montana, those who were exposed to asbestos in Libby have begun seeing their portion of the (Source: Asbestos and Mesothelioma News)
Synthesis, characterization and antiproliferative activity on mesothelioma cell lines of bis(carboxylato)platinum(IV) complexes based on picoplatin
Dalton Trans., 2012, Advance ArticleDOI: 10.1039/C2DT11874B, PaperMauro Ravera, Elisabetta Gabano, Ilaria Zanellato, Ilaria Bonarrigo, Esther Escribano, Virtudes Moreno, Merce Font-Bardia, Teresa Calvet, Domenico OsellaPicoplatin-based Pt(IV) complexes with axial carboxylato ligands, bypassing chemoresistance to cisplatin, are reported for the first time.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Dalton Trans. latest articles)
Preclinical studies identify novel targeted pharmacological strategies for treatment of human malignant pleural mesothelioma
SummaryThe incidence of human malignant pleural mesothelioma (hMPM) is still increasing worldwide. hMPM prognosis is poor even if the median survival time has been slightly improved after the introduction of the up?to?date chemotherapy. Nevertheless, large phase II/III trials support the combination of platinum?derivatives and pemetrexed or raltitrexed, as preferred first?line schedule. Better understanding of the molecular machinery of hMPM will lead to the design and synthesis of novel compounds targeted against pathways identified as crucial for hMPM cell proliferation and spreading. Among them, several receptors tyrosine kinase show altered activity in subsets of hMPM. This observation suggests that these kinases might represent novel therapeutic targets in this chemotherapy?...
The Antioxidants Vitamins A and E and Selenium Do Not Reduce the Incidence of Asbestos-Induced Disease in a Mouse Model of Mesothelioma.
Authors: Robinson C, Woo S, Walsh A, Nowak AK, Lake RA Abstract Epidemiological evidence indicates that supplementation with some dietary factors is associated with a lower incidence of cancer. An effective cancer prevention strategy for the millions of people worldwide who have been exposed to asbestos could have enormous benefit. We tested whether dietary supplementation of the antioxidants vitamin A, E, and selenium could alter the pattern of disease in the MexTAg transgenic mouse model, in which mice uniformly develop mesothelioma after asbestos exposure. We focused on antioxidants because one of the most widely accepted hypotheses for the mechanism by which asbestos fibers cause cancer proposes the involvement of reactive oxygen and nitrogen species. We compared the survival o...
Appeal Begins Involving $15.2 million Award for Worker Exposed to Asbestos in Oil-Drilling Mud
Conoco Phillips Corp. has begun its appeal before the Mississippi Supreme Court concerning the $15.2 million award that was given to a worker who was exposed to asbestos by the additive he was mixing with oil-drilling mud. (Source: Asbestos and Mesothelioma News)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.januarysales.org/" target="_blank">January Sales</a> in the UK.</p></div>
A comparison of epidermal growth factor receptor expression in malignant peritoneal and pleural mesothelioma
An evaluation of epidermal growth factor receptor (EGFR) phenotypic expression in malignant pleural and peritoneal mesothelioma was undertaken, using immunohistochemical (IHC) and fluorescence in situ hybridization (FISH) analysis. Thirty?eight malignant mesothelioma (MM) specimens were subjected to IHC staining and FISH to evaluate the expression of EGFR protein and gene status. Overall positive IHC reaction was detected in 20/38 (53%) cases, in 11/22 (50%) pleural MM, and in 9/16 (56%) peritoneal MM. Our study confirmed that EGFR membranous expression is a common feature in MM, but not in benign mesothelial lesion. Thirty?seven cases did not show a gene copy number gain. Only one case showed a copy number gain. The protein overexpression of EGFR was not related to a gene copy number ...
Week in Review at the Mesothelioma Center: Alarming Asbestos News
The Week in Review at the Mesothelioma Center included helpful proposed legislation, an alarming report about asbestos imports, the small-cell lung cancer that killed the legendary coach and a good-looking donation by a drug company. (Source: Asbestos and Mesothelioma News)
Congressman Promotes Legislation To Speed Up Drug Development for Diseases Like Mesothelioma
U.S. Rep. Leonard Lance is promoting a piece of legislation designed to speed the process of getting new drugs and treatments for rare diseases like mesothelioma/ to patients. The bill is in front of the Health Subcommittee. (Source: Asbestos and Mesothelioma News)
High Wilms? tumour gene (WT1) expression and low mitotic count are independent predictors of survival in diffuse peritoneal mesothelioma
Conclusions:? Our study suggests that low WT1 expression and high MC may be indicative of an unfavourable prognosis in patients with advanced malignant peritoneal mesothelioma. (Source: Histopathology)
PRAME (Preferentially Expressed Antigen of Melanoma) Is a Novel Marker for Differentiating Serous Carcinoma From Malignant Mesothelioma.
The objective of this study was to validate this finding at the messenger RNA (mRNA) and protein levels. Quantitative real-time polymerase chain reaction analysis of 126 müllerian carcinomas and 23 malignant mesotheliomas showed significantly higher PRAME mRNA expression in the former tumor (P &lt; .001; test sensitivity and specificity, 89% and 91%, respectively). PRAME protein was expressed in 41 of 50 müllerian carcinomas and 0 of 30 mesotheliomas using Western blotting (P &lt; .001; test sensitivity and specificity, 82% and 100%, respectively). PRAME levels in müllerian carcinoma were unrelated to survival; however, PRAME protein expression was up-regulated in solid metastases compared with primary carcinoma and effusions (P &lt; .001). Our data confirm that PRAME effectively differ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Please support the <a href="http://www.doctorsinchains.org/" target="_blank">Doctors In Chains</a> campaign for the <a href="http://www.doctorsinchains.org/">medics</a> tortured and sentenced for up to 15 years in <a href="http://www.doctorsinchains.org/">Bahrain</a>. <a href="https://twitter.com/#!/search/%23FreeDoctors">#FreeDoctors</a></p></div>
Asbestos Imports Have Started to Rise Again, Fueled by Manufacturers? Demands
Although the dangers of asbestos are well known, the importing of the toxic mineral has started to increase again, according to the 2012 United States Geological Survey Mineral Commodity Summaries. (Source: Asbestos and Mesothelioma News)
Report: Almost Half of All Cancers Caused by Lifestyle Choices
A report from the Cancer Research UK has reported that 45 percent of cancers in men and 40 percent of cancers in women could be prevented by living a healthier lifestyle, citing that four lifestyle choices contribute to over 100,000 cancers. (Source: Asbestos and Mesothelioma News)
Asbestos a Risk Factor In Small-Cell Lung Cancer that Killed Ex-Penn State Coach Joe Paterno
Former Penn State football coach Joe Paterno was a non-smoker throughout his life, which gave him little chance of getting the small-cell lung cancer. But that's what killed him, making asbestos exposure a question to ask about his life (Source: Asbestos and Mesothelioma News)
DNA methylation status of REIC/Dkk-3 gene in human malignancies
Conclusions&nbsp;&nbsp; REIC/Dkk-3 type-a methylation was frequently detected in a broad range of cancers and appeared to play a key role in silencing REIC/Dkk-3 type-a expression in these malignancies. Content Type Journal ArticleCategory Original PaperPages 1-11DOI 10.1007/s00432-012-1158-6Authors Tatsuro Hayashi, Department of Cancer and Thoracic Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Okayama, 700-8558 JapanHiroaki Asano, Department of Cancer and Thoracic Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Okayama, 700-8558 JapanShinichi Toyooka, Department of Cancer and Thoracic Surgery, Graduate School of Medicine, Dentistry and Pharm...
Heme Oxygenase-1 Promoter Polymorphism is Associated with Risk of Malignant Mesothelioma
Conclusion&nbsp;&nbsp;The findings of this study suggest that long (GT)n repeats in the HO-1 gene promoter are associated with a higher risk of malignant mesothelioma in the Japanese population. Content Type Journal ArticlePages 1-5DOI 10.1007/s00408-012-9371-2Authors Aki Murakami, Division of Respiratory Medicine, Department of Internal Medicine, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo, 663-8501 JapanYoshihiro Fujimori, Hyogo College of Medicine, Cancer Center, 1-1 Mukogawa-cho, Nishinomiya, Hyogo, 663-8501 JapanYoshie Yoshikawa, Department of Genetics, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo, 663-8501 JapanShusai Yamada, Division of Respiratory Medicine, Department of Internal Medicine, Hyogo College of Medicine, 1-1 Mukogawa-ch...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.januarysales.org/" target="_blank">January Sales</a> in the UK.</p></div>
Bristol-Myers Squibb Donates $6.9 Million for Patients of Cancers Like Mesothelioma
On Thursday, Bristol-Myers Squibb announced that the company donated $6.9 million in 2011 to HealthWell Foundation, a non-profit that is dedicated to providing financial assistance for treatments for cancers like mesothelioma. (Source: Asbestos and Mesothelioma News)
Week in Review: Asbestos Violations, Promising Mesothelioma Research and More Awareness
Researchers examine the Navy's role in asbestos exposure, while a state lawmaker raises the awareness by a lung cancer announcement, all part of The Week in Review at the Mesothelioma Center. (Source: Asbestos and Mesothelioma News)
New Mexico Lawmaker Blames Asbestos Exposure for Stage IV Lung Cancer
New Mexico House Speaker Ben Lujan, 76, has stage 4 lung cancer diagnosed back in 2009. Since he was not a smoker, he believes his cancer is a result of asbestos exposure while working as an iron worker in a previous job. (Source: Asbestos and Mesothelioma News)
Louisiana Man Caught Burning Asbestos Shingles for 2nd Time Slapped with Fine
After failing to learn his lesson the first time, a Louisiana man is sentenced by District Court Judge for violating strict laws against burning asbestos shingles. (Source: Asbestos and Mesothelioma News)
Epithelial Malignant Pleural Mesothelioma After Extrapleural Pneumonectomy: Stratification of Survival With CT-Derived Tumor Volume
CONCLUSION. With control of prognostic covariates, CT-derived tumor volume can be used to stratify survival of patients with epithelial mesothelioma after extrapleural pneumonectomy and should be included in prognostic evaluation of patients for whom resection is being considered. (Source: American Journal of Roentgenology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Please support the <a href="http://www.doctorsinchains.org/" target="_blank">Doctors In Chains</a> campaign for the <a href="http://www.doctorsinchains.org/">medics</a> tortured and sentenced for up to 15 years in <a href="http://www.doctorsinchains.org/">Bahrain</a>. <a href="https://twitter.com/#!/search/%23FreeDoctors">#FreeDoctors</a></p></div>
Researchers Investigate How Gene Mutations Relate To Lung Cancer of Nonsmokers
Researchers identified distinct gene mutations that exist in lung cancer cases in individuals who have never smoked. The long-term implications of the research may be tremendous for all those affected by this disease. (Source: Asbestos and Mesothelioma News)
Expression of Interleukin-4 Receptor Alpha by Human Pleura Mesothelioma is Associated with Poor Survival and Promotion of Tumor Inflammation.
CONCLUSIONS: Tumor expression of IL-4Ra is inversely correlated with survival in patients undergoing surgical resection for epithelial MPM. Tumor-infiltrating T cells in MPM are polarized to produce IL-4 and may provide endogenous activation signals to MPM tumor cells in situ. The IL-4/IL-4 receptor axis is a potential therapeutic target in human MPM. PMID: 22261806 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)
CD26 overexpression is associated with prolonged survival and enhanced chemosensitivity in malignant pleural mesothelioma.
CONCLUSIONS: Our results strongly suggest that CD26 is a clinically significant biomarker for predicting response to chemotherapy for MPM. PMID: 22261805 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)
New Report Shines Light on Navy?s Knowledge of Asbestos Dangers
According to a report by ChemRisk, the Navy continued to mandate that asbestos-containing materials be used on their ships even as mesothelioma and other diseases were clearly being linked to asbestos exposure. (Source: Asbestos and Mesothelioma News)
Rab25 is overexpressed in Müllerian serous carcinoma compared to malignant mesothelioma
The objective of this study was to validate this finding at the mRNA and protein level. Quantitative PCR analysis of 112 Müllerian serous carcinomas (84 effusions, 28 primary ovarian carcinomas) and 22 malignant mesotheliomas (19 effusions, 3 solid specimens) showed significantly higher RAB25 mRNA expression in the former tumor (p?&lt;?0.001). Immunohistochemical analysis of Rab25 protein expression in 245 effusions showed significantly higher expression of this protein in Müllerian serous carcinoma compared to malignant mesothelioma (189/209 vs. 12/36 positive tumors, respectively; p?&lt;?0.001). Immunostaining of 101 patient-matched solid Müllerian carcinoma specimens (34 primary carcinomas, 67 metastases) showed expression levels comparable to effusions (94/101 positive...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.januarysales.org/" target="_blank">January Sales</a> in the UK.</p></div>
Roshi Chadha Resigns from Red Cross Board Because of Asbestos Industry Ties
Days after receiving a vote of confidence, Roshi Chadha resigned from the Canadian Red Cross board of directors because of her ties to the asbestos industry and pressure from the anti-asbestos lobby. (Source: Asbestos and Mesothelioma News)
Data-driven information retrieval in heterogeneous collections of transcriptomics data links SIM2s to malignant pleural mesothelioma
Motivation: Genome-wide measurement of transcript levels is an ubiquitous tool in biomedical research. As experimental data continues to be deposited in public databases, it is becoming important to develop search engines that enable the retrieval of relevant studies given a query study. While retrieval systems based on meta-data already exist, data-driven approaches that retrieve studies based on similarities in the expression data itself have a greater potential of uncovering novel biological insights. Results: We propose an information retrieval method based on differential expression. Our method deals with arbitrary experimental designs and performs competitively with alternative approaches, while making the search results interpretable in terms of differential expression patterns. We ...
Mechanism for Expansile Nanoparticle Uptake in Mesothelioma
Conclusions: Uptake of expansile nanoparticles by tumor cells utilizes pathways of macropinocytosis. This pathway is non-receptor dependent thus allowing rapid nanoparticle uptake to occur in tumors of various cell origins; thus explaining similar anti-tumor efficacy against breast and ovarian carcinoma in vivo. (Source: Journal of Surgical Research)
Simmons Firm Appoints New Shareholder, Strengthens Commitment to...
Litigator and mesothelioma advocate appointed as new shareholder for leading national law firm(PRWeb January 11, 2012)Read the full story at http://www.prweb.com/releases/2012/1/prweb9093188.htm (Source: PRWeb: Medical Pharmaceuticals)
Mesothelioma Center Week In Review: A Look To the Future, A Glance At the Past for Mesothelioma
Asbestos abatement violators go to trial, Orphan Drug Designation comes alive, Steve McQueen and Warren Zevon all take the stage at the Mesothelioma Center this week. (Source: Asbestos and Mesothelioma News)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Please support the <a href="http://www.doctorsinchains.org/" target="_blank">Doctors In Chains</a> campaign for the <a href="http://www.doctorsinchains.org/">medics</a> tortured and sentenced for up to 15 years in <a href="http://www.doctorsinchains.org/">Bahrain</a>. <a href="https://twitter.com/#!/search/%23FreeDoctors">#FreeDoctors</a></p></div>
Trial Starts for Men Accused of Illegally Removing Asbestos from Salvage Site
Three men are on trial in a U.S. District Court in Chattanooga after being accused of illegally removing asbestos from a salvage site, according to an 11-count indictment from a federal grand jury. (Source: Asbestos and Mesothelioma News)
ADAO Will Honor Mesothelioma Victim Steve McQueen at 8th Annual Convention
Actor Steve McQueen is one of several well-known Americans to fall victim to mesothelioma. He will be honored in March at the Asbestos Disease Awareness Organization's annual convention. (Source: Asbestos and Mesothelioma News)
ERRATUM for a missing eComment 'Malignant pleural mesothelioma: a therapeutic challenge'
(Source: Interactive CardioVascular and Thoracic Surgery)
Inpsector General: EPA Lacks Regulation of Nanomaterials
The Environmental Protection Agency doesn't have the data or ability to manage the challenges associated with nanomaterials, concludes a recent report from the EPA's Office of Inspector General. (Source: Asbestos and Mesothelioma News)
Practical approaches to diagnose and treat for T0 malignant pleural mesothelioma: a proposal for diagnostic total parietal pleurectomy
Abstract&nbsp;&nbsp;Malignant pleural mesothelioma (MPM) remains suffering poor prognosis in spite of recent diagnostic and therapeutic progress. Although there is currently no established evidence, early diagnosis and early intervention may play a key role to improve prognosis of MPM, similarly to other malignancies. As pleural effusion is usually the first clinical sign of MPM, pleural effusion cytology is often the first diagnostic examination to be carried out. Since the sensitivity of pleural effusion cytology is approximately 60%, however, false-negative diagnosis is given to almost half of true MPM patients at this clinical step. One practical way to reduce the number of misdiagnosed MPM is to encourage performing thoracoscopic pleural biopsy unless definitive diagnosis other ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.januarysales.org/" target="_blank">January Sales</a> in the UK.</p></div>
Pathological and molecular biological approaches to early mesothelioma
Abstract&nbsp;&nbsp;Malignant mesothelioma is an asbestos-related malignancy that arises primarily from mesothelial cells on the serosal surfaces of the pleural, peritoneal, and pericardial cavities. Malignant pleural mesothelioma (MPM) is most common, and its incidence is dramatically increasing worldwide as a result of widespread use of asbestos. Morphological discrimination between MPM and reactive mesothelial hyperplasia is difficult, and the most reliable pathological criterion for malignancy is mesothelial proliferation invading deeply into subpleural adipose tissues. To establish radical cure of MPM, it is crucial to find early-stage MPM of epithelial type, in which mesothelial proliferation is localized on the serosal surface of parietal pleura or limited within the submesoth...
Choice of rating method for assessing occupational asbestos exposure: Study for compensation purposes in France
ConclusionThis study shows that the two rating systems have good or very good agreement. These results validate the routine use in the PNSM of the ?by subject? rating, with the advantage of being convenient and quick to provide feedback on occupational asbestos exposure to mesothelioma cases for compensation. Am. J. Ind. Med. © 2012 Wiley Periodicals, Inc. (Source: American Journal of Industrial Medicine)
EPA, Federal Courts Continue Crackdown on Violations of Asbestos Regulations
The EPA is asking a federal district court in New Jersey to access a hefty fine against Lovett Contracting, just the latest violator of (Source: Asbestos and Mesothelioma News)
Early mesothelioma revisited
Content Type Journal ArticleCategory Introduction to Review ArticlesPages 1-3DOI 10.1007/s10147-011-0365-5Authors Seiki Hasegawa, Department of Thoracic Surgery, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, 663-8501 Japan Journal International Journal of Clinical OncologyOnline ISSN 1437-7772Print ISSN 1341-9625 (Source: International Journal of Clinical Oncology)
Estimating the asbestos-related lung cancer burden from mesothelioma mortality
Authors: V McCormack, J Peto, G Byrnes, K Straif & P Boffetta (Source: British Journal of Cancer AOP)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Please support the <a href="http://www.doctorsinchains.org/" target="_blank">Doctors In Chains</a> campaign for the <a href="http://www.doctorsinchains.org/">medics</a> tortured and sentenced for up to 15 years in <a href="http://www.doctorsinchains.org/">Bahrain</a>. <a href="https://twitter.com/#!/search/%23FreeDoctors">#FreeDoctors</a></p></div>
miR-34a Expression, Cell Cycle Arrest and Cell Death of Malignant Mesothelioma Cells upon Treatment with Radiation, Docetaxel or Combination Treatment.
Conclusion: Microtubule formation and other related functions by docetaxel might be the most suitable treatment modulation in both sarcomatoid and epithelial types of MM. PMID: 22237142 [PubMed - as supplied by publisher] (Source: Oncology)
Clinical Treatment CBP501 Receives FDA Orphan Drug Designation for Mesothelioma
CBP501, made by CanBas Co., is being tested as a treatment for mesothelioma. With the FDA's recent Orphan Drug Designation, the company can now receive incentives to continue pursuing their treatment for the rare cancer. (Source: Asbestos and Mesothelioma News)
Asbestos Week in Review: Schools, Bankruptcy, Verdicts, Aggressive Surgeries and Presidential Campaigns
This week in the Mesothelioma Center, there was all sorts of news: A bankruptcy, a reversed asbestos verdict, schools awaiting costly abatement and more debate over the use of EPP surgery. (Source: Asbestos and Mesothelioma News)
Report: Cancer Deaths and Lung Cancer Deaths Down Over 20-Year Period
Cancer-related deaths, including those by lung cancer, continued to decrease over the past 20 years, the American Cancer Society reported. The study estimates that more than 1 million cancer deaths have been avoided. (Source: Asbestos and Mesothelioma News)
Upregulated p53 expression activates apoptotic pathways in wild-type p53-bearing mesothelioma and enhances cytotoxicity of cisplatin and pemetrexed
Authors: Q Li, K Kawamura, M Yamanaka, S Okamoto, S Yang, S Yamauchi, T Fukamachi, H Kobayashi, Y Tada, Y Takiguchi, K Tatsumi, H Shimada, K Hiroshima & M Tagawa (Source: Cancer Gene Therapy)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.januarysales.org/" target="_blank">January Sales</a> in the UK.</p></div>
Mesotheliomas with small cell features: report of eight cases
Modern Pathology advance online publication, January 6, 2012. doi:10.1038/modpathol.2011.202 Author: Nelson G Ord&#243;&#241;ez (Source: Modern Pathology AOP)
Canadian Asbestos Mine Could Reopen Despite Bankruptcy Filing
Filing for bankruptcy won't stop owners of asbestos mine in Canada from moving forward with plans to restart production in the future. (Source: Asbestos and Mesothelioma News)
Mississippi Judge Throws Out Record $322 Million Lawsuit Verdict
Thomas Brown won $322 million in his asbestos lawsuit against Union Carbide and Chevron Oil in 2011, but a Mississippi judge rescinded the verdict, agreeing with Union Carbide that the presiding judge should have disclosed that his parents had been involved in unrelated asbestos litigation against one of the defendants. A new trial is scheduled for April. (Source: Asbestos and Mesothelioma News)
Study: Risky Mesothelioma Treatment Improves Patient Quality of Life
Researchers have concluded that a controversial treatment option known as extrapleural pneumonectomy may provide more significant benefits on the quality of life in mesotheliomapatients than previously thought. (Source: Asbestos and Mesothelioma News)
Mesothelioma Patient and Air Force Veteran Campaigning For Rick Perry In Iowa
A diagnosis of mesothelioma didn't stop Air Force veteran Patrick Burke from joining Rick Perry's presidential campaign before the Iowa Caucus. Campaigning was on Burke's "bucket list." (Source: Asbestos and Mesothelioma News)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Please support the <a href="http://www.doctorsinchains.org/" target="_blank">Doctors In Chains</a> campaign for the <a href="http://www.doctorsinchains.org/">medics</a> tortured and sentenced for up to 15 years in <a href="http://www.doctorsinchains.org/">Bahrain</a>. <a href="https://twitter.com/#!/search/%23FreeDoctors">#FreeDoctors</a></p></div>
Vatalanib ineffective against malignant mesothelioma
NEW YORK (Reuters Health) - Monotherapy with vatalanib is ineffective against malignant mesothelioma, according to new results from the Cancer and Leukemia Group B. (Source: Modern Medicine)
Malignant mesothelioma of the tunica vaginalis testis: diagnostic studies and differential diagnosis.
Authors: Chekol SS, Sun CC Abstract Malignant mesothelioma of the tunica vaginalis testis is an extremely rare tumor representing 0.3% to 5% of all malignant mesotheliomas. Gross examination of testicular mesotheliomas typically reveals tumor nodules studding the thickened tunica vaginalis and, in some cases, infiltrating the testicular parenchyma, leading to diagnostic challenges. Microscopically, the tumor is characterized by epithelioid cells arising from the tunica vaginalis with papillary, tubulopapillary, or solid architectural patterns. The papillae are usually lined by a single layer of cells with relatively bland cytologic features. An epithelial cell phenotype admixed with a sarcomatoid pattern has also been described in a few cases. Immunohistochemically, the tumor is us...
Week In Review: Asbestos Disappearing in Canada, Deadline in NYC, Firefighters in Washington
The Mesothelioma Center's week in review includes the decline of asbestos support in Canada, a deadline for Victim Compensation Fund applicants in New York City and a health care settlement for firefighters in Washington. (Source: Asbestos and Mesothelioma News)
Asbestos Abatement Proves Costly for Massachusetts High School
Newton North High School spent nearly $14 million for the building demolition because of increased costs of removing asbestos. The school was initially supposed to cost $40 million, but now, the total costs are estimated at more than $190 million. (Source: Asbestos and Mesothelioma News)
Primary pleural angiosarcoma as a mimicker of mesothelioma: a case report
We report the case of a 49-year-old male patient with primary pleural angiosarcoma, who presented with initial hemothorax, followed by a rapid progress to an inoperable status. (Source: Diagnostic Pathology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.januarysales.org/" target="_blank">January Sales</a> in the UK.</p></div>
Deadline Approaching For Pending Lawsuits Regarding 9/11 and Compensation Fund
Anyone wanting to apply for inclusion in the government's Victims Compensation Fund regarding the 9/11 terrorist attack of the World Trade Center must withdraw a pending lawsuit by Jan. 2, 2012. It is the latest hard decision to make for those who fear mesothelioma cancer from intense asbestos exposure. (Source: Asbestos and Mesothelioma News)
Asbestos Awareness Group Details 2012 Asbestos Conference
The Asbestos Disease Awareness Organization recently announced who the keynote speaker and honorees will be for the 8th Annual International Asbestos Awareness Conference. The event strives to end the development of asbestos-related diseases like mesothelioma. (Source: Asbestos and Mesothelioma News)
Firefighters Receive Lifetime Health Monitoring After Dangerous Asbestos Exposure
The city of Everett,. Washington agreed to pay for lifetime health monitoring for fighters who were exposed to asbestos during faulty training sessions, as a part of a legal settlement. (Source: Asbestos and Mesothelioma News)
Mesothelioma risk persists after asbestos exposure
NEW YORK (Reuters Health) - French researchers say the risk of pleural mesothelioma seems to increase for up to 30 years after occupational asbestos exposure. (Source: Modern Medicine)
Pacific Meso Center opens free-standing mesothelioma research lab
Pacific Meso Center has opened a new state-of-the-art mesothelioma research laboratory dedicated solely to the discovery of new treatments for malignant pleural mesothelioma, a cancer of the chest lining caused by asbestos exposure. Pacific Meso Center, a division of the nonprofit Pacific Heart, Lung & Blood Institute, said the lab at 10780 Santa Monica Blvd. in Los Angeles is the first of its kind in the world, and was ?established to lead a focused and collaborative mesothelioma research effort that is independent of the limitations often imposed by academic as well as private medical institutions... (Source: bizjournals.com Health Care:Physician Practices headlines)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Please support the <a href="http://www.doctorsinchains.org/" target="_blank">Doctors In Chains</a> campaign for the <a href="http://www.doctorsinchains.org/">medics</a> tortured and sentenced for up to 15 years in <a href="http://www.doctorsinchains.org/">Bahrain</a>. <a href="https://twitter.com/#!/search/%23FreeDoctors">#FreeDoctors</a></p></div>
Week in Review: Asbestos Still Threatens Everyone Despite Reduction in Use
The Week in Review at the Mesothelioma Center touched on a variety of issues, including the continued threat posed by the toxic mineral. (Source: Asbestos and Mesothelioma News)
Experimental Asbestos Demolition in Fort Worth, Texas Considered Health Risk
Asbestos abatement at the Fort Worth's Oak Hollow apartments was performed under the "wet method," which has not been approved by the EPA. Construction workers and local residents may have been exposed to asbestos during the procedure. (Source: Asbestos and Mesothelioma News)
National Cancer Institute Opening 2 New Trials For Mesothelioma Patients
With a rare cancer like (Source: Asbestos and Mesothelioma News)
Clinical Impact of Extrapleural Pneumonectomy for Malignant Pleural Mesothelioma
Conclusions&nbsp;&nbsp;Extrapleural pneumonectomy has a significant and durable impact on function and symptoms as well as on physical and mental components of quality of life in patients with malignant pleural mesothelioma. Content Type Journal ArticleCategory Thoracic OncologyPages 1-8DOI 10.1245/s10434-011-2171-8Authors Vincenzo Ambrogi, Department of Thoracic Surgery, Tor Vergata University, Rome, ItalyAlfonso Baldi, Department of Biochemistry, Section of Pathology, Second University of Naples, Naples, ItalyOrazio Schillaci, Department of Biopathology and Diagnostic Imaging, Tor Vergata University, Rome, ItalyTommaso Claudio Mineo, Department of Thoracic Surgery, Tor Vergata University, Rome, Italy Journal Annals of Surgical OncologyOnline ISSN 1534-4681Print ISSN 10...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.januarysales.org/" target="_blank">January Sales</a> in the UK.</p></div>
New York Firefighters Concerned after Asbestos Confirmed at Firehouse
Lackawanna firefighters have expressed serious concerns after tests confirm that asbestos fibers were present in the firehouse where they worked. The firemen were evacuated from Fire House 3 at 2990 South Park Ave. on Saturday after two samples tested positive for asbestos. (Source: Asbestos and Mesothelioma News)
BRCA1 is an essential mediator of vinorelbine induced apoptosis in mesothelioma
AbstractTherapeutic options for malignant pleural mesothelioma (MPM) are limited despite the increasing incidence globally. The vinca alkaloid, vinorelbine exhibits clinical activity, however, to date, treatment optimization has not been achieved using biomarkers. BRCA1 regulates sensitivity to microtubule poisons, however its role in regulating vinorelbine induced apoptosis in mesothelioma is unknown. Here we demonstrate that BRCA1 plays an essential role in mediating vinorelbine induced apoptosis, as evidenced by: 1) the strong correlation between vinorelbine sensitivity and BRCA1 expression level, 2) induction of resistance to vinorelbine by BRCA1 using siRNA oligonucleotides, 3) dramatic downregulation of BRCA1 following selection for vinorelbine resistance, and 4) the re?activation ...
EPA Questions Its Own Approval Of Experimental Method For Asbestos Demolition
The Environmental Protection Agency (EPA) finds itself under fire in Fort Worth, Texas, because of an experimental method for handling asbestos before a building is destroyed. (Source: Asbestos and Mesothelioma News)
Pericardial synovial sarcoma, a potential for misdiagnosis: clinicopathologic and molecular cytogenetic analysis of three cases with literature review.
In this report, we describe 3 cases of synovial sarcoma that manifested clinically as primary pericardial lesions. All 3 cases occurred in men in their fourth decade. Fever, cough, chest pain, and chest distress were the most common symptoms. Histologically, 2 of the tumors were spindle cell monophasic, and 1 tumor was biphasic. By immunohistochemical studies, the tumor cells were positive for cytokeratins and epithelial membrane antigen. In addition, the tumor cells displayed focal immunoreactivity for calretinin, cytokeratin 5/6, and HBME-1, resulting in the initial interpretations of malignant mesotheliomas. None of the 3 cases were diagnosed correctly until subsequent molecular cytogenetic assays demonstrated the presence of SYT gene rearrangements. As there are overlapping morphologic...
Benign multicystic mesothelioma with concurrent colonic adenocarcinoma: a report of two cases
In this report, we present two cases of BMM detected in females with concurrent colonic adenocarcinoma arising in the ileocecal region. The tumors were present in the serosa surrounding the colonic adenocarcinoma in one case, and in the omentum in the other case, which grossly mimicked peritoneal seeding of carcinoma. An immunohistochemical analysis revealed that the cells lining the cystic spaces in both lesions were positive for keratin and calretinin, confirming their mesothelial origin. To the best of our knowledge, these cases represent the first documented examples of multicystic mesothelioma concurrent with colonic adenocarcinoma. Content Type Journal ArticleCategory Case ReportPages 1-5DOI 10.1007/s00595-011-0099-zAuthors Anwar Husain, Lombardi Comprehensive Cancer Cent...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Please support the <a href="http://www.doctorsinchains.org/" target="_blank">Doctors In Chains</a> campaign for the <a href="http://www.doctorsinchains.org/">medics</a> tortured and sentenced for up to 15 years in <a href="http://www.doctorsinchains.org/">Bahrain</a>. <a href="https://twitter.com/#!/search/%23FreeDoctors">#FreeDoctors</a></p></div>
Mesothelioma Lawsuit Reveals Rare Case of Short Asbestos Exposure
Roger Hammett was awarded $1.45 million in a mesothelioma lawsuit, after his cancer was caused by asbestos exposure after just 67 days of exposure. Most cases of mesothelioma involve years of occupational exposure, but Hammett developed cancer after less than two months of work. (Source: Asbestos and Mesothelioma News)
Week In Review: Promising Mesothelioma Study And Red Cross Exec Under Fire For Asbestos Ties
In the news this week at the (Source: Asbestos and Mesothelioma News)
EPA Inspector General Elkins Challenges Agency?s Policies On Asbestos
The government entity responsible for protecting citizens from environmental dangers like asbestos is the same agency that is endangering its employees through asbestos exposure, reports the agency's own inspector general. asbestos (Source: Asbestos and Mesothelioma News)
Photodynamic Therapy For Mesothelioma Patients Should Improve With PHOTOFRIN Approval
Photodynamic therapy (PDT) for mesothelioma patients got a boost when PHOTOFRIN obtained Orphan Drug Designation. PHOTOFRIN is often prescribed following surgery and chemotherapy for malignant mesothelioma cancer. (Source: Asbestos and Mesothelioma News)
Functional Characterization of an scFv-Fc Antibody that Immunotherapeutically Targets the Common Cancer Cell Surface Proteoglycan CSPG4
Cell surface chondroitin sulfate proteoglycan 4 (CSPG4) is an attractive target for antibody-based cancer immunotherapy because of its role in tumor cell biology, its high expression on malignant cells including cancer-initiating cells, and its restricted distribution in normal tissues. The clinical use of CSPG4 has been hampered by the lack of a CSPG4-specific chimeric, humanized, or fully human monoclonal antibody. To overcome this limitation, we generated a CSPG4-specific fully human single-chain antibody termed scFv-FcC21 and characterized its specificity and antitumor activity. Viable CSPG4+ melanoma cells were used in a screen of a human scFv phage display library that included CDR3 engineered to optimize antibody binding sites. The scFv antibody isolated was then recombinantly engin...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.januarysales.org/" target="_blank">January Sales</a> in the UK.</p></div>
Differentiation of malignant pleural mesothelioma from other pleural diseases
In this study, pleural effusion samples from 101 patients with suspected or newly diagnosed malignant pleural mesothelioma (MPM) or metastatic adenocarcinoma (ADCA) were collected between 1998 and 2010. Of the 101 patients, 65 were diagnosed with MPM, 25 with ADCA and 15 with benign pleural effusion. Cancer cells isolated from pleural effusion samples were subjected to genome-wide gene expression analysis, done with the help of microarrays and real-time PCR. The study found 74 genes coding for markers that were overexpressed in MPM and 9 genes that were overexpressed in ADCA. The highest expression in MPM cells was the gene COL3A1, coding for type III collagen. Immunohistochemistry demonstrated 100% staining of MPM biopsy samples with antibodies specific for COL3A1 and no staining in ADCA....
Canadian Red Cross May Remove Board Member Roshi Chada Because Of Asbestos Ties
Anti-asbestos advocates are pushing for the removal of Red Cross executive board member Roshi Chadha because of ties she has to the asbestos industry. Her husband, Baljit Chadha, is president of Balcorp, a company that has a subsidiary that transports asbestos. (Source: Asbestos and Mesothelioma News)
Canadian Red Cross May Remove Board Member Roshi Chadha Because Of Asbestos Ties
Anti-asbestos advocates are pushing for the removal of Red Cross executive board member Roshi Chadha because of ties she has to the asbestos industry. Her husband, Baljit Chadha, is president of Balcorp, a company that has a subsidiary that transports asbestos. (Source: Asbestos and Mesothelioma News)
Mesothelioma Claims Another Actor: Australia?s Harold Hopkins
Longtime Australian Actor Harold Hopkins, known for his role in Gallipoli, died Sunday of mesothelioma cancer at a hospital in Sydney, Australia. Hopkins's family said the disease stemmed from his exposure to asbestos from his days as a carpenter apprentice in the 1960s. (Source: Asbestos and Mesothelioma News)
Genomic gains and losses in malignant mesothelioma demonstrated by FISH analysis of paraffin-embedded tissues
Conclusions The authors found various genomic gains and losses in MM by FISH analysis. The frequency of each genomic gain or loss examined in MM by FISH analysis almost agreed with the comparative genomic hybridisation technique in previous studies. This study suggests that genomic evaluation by FISH analysis might be helpful in distinguishing MM from benign mesothelial proliferation. (Source: Journal of Clinical Pathology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Please support the <a href="http://www.doctorsinchains.org/" target="_blank">Doctors In Chains</a> campaign for the <a href="http://www.doctorsinchains.org/">medics</a> tortured and sentenced for up to 15 years in <a href="http://www.doctorsinchains.org/">Bahrain</a>. <a href="https://twitter.com/#!/search/%23FreeDoctors">#FreeDoctors</a></p></div>
American Companies Warned about Buying Improperly Labeled Asbestos Products
American companies purchased products that contained asbestos but were labeled as "non-asbestos containing." The names of the companies were not released, but handlers or end-users may be at risk of asbestos exposure if the products are disturbed or damaged. Lawsuits are expected to follow. (Source: Asbestos and Mesothelioma News)
A Patriotic Week in Review for Veterans and Mesothelioma Center
Navy veteran Frank Curre loved Pearl Harbor Day, not for the death and destruction it originally brought, but for the patriotism it invoked every year. He fought to see it one last time. Curre was 18 years old and aboard the USS Tennessee when he survived the Japanese attack at Pearl Harbor that drew Americans [...] (Source: Asbestos and Mesothelioma News)
Arkansas Community Fears Possible Asbestos Contamination
Officials from the Environmental Protection Agency met with community members in North Little Rock on December 8 to discuss the possible presence of asbestos exposure in the area where a vermiculite processing facility operated in prior years. Further testing is expected as residents await. (Source: Asbestos and Mesothelioma News)
Obama, Harper Urged To Help Stop Asbestos Import, Export and Production
Critics of the asbestos industry are pushing President Obama and Canadian Prime Minister Stephen Harper to stop the import, export and production of asbestos in North America. (Source: Asbestos and Mesothelioma News)
?-catenin expression in benign and malignant pleural disorders.
Authors: Anani W, Bruggeman R, Zander DS Abstract Benign and malignant pleural processes display a large and overlapping spectrum of morphological appearances, and can be difficult to distinguish, histologically, from each other. ?-catenin, a participant in the wingless-type (Wnt) transduction pathway, is involved in the pathogenesis of malignant mesothelioma and has received limited evaluation for its ability to serve as a diagnostic aid for distinguishing between individual pleural disorders. We performed immunohistochemistry for ?-catenin on 10 pleural malignant mesotheliomas, 10 examples of mesothelial hyperplasia and 18 cases of organizing pleuritis. Although differences were noted in staining intensity between the mesothelioma and mesothelial hyperplasia groups, extensivene...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.januarysales.org/" target="_blank">January Sales</a> in the UK.</p></div>
Nation Remembers Veterans on 70th Anniversary of Pearl Harbor Attack
Seventy years to the day, the United States was attacked at Pearl Harbor. Today we honor all survivors and past veterans of the attack. Over 2,400 Americans lost their lives. Some survivors are dealing with more than the bad memories of the attack; they are also dealing with mesothelioma. (Source: Asbestos and Mesothelioma News)
Taking Aim at Malignant Pleural MesotheliomaTaking Aim at Malignant Pleural Mesothelioma
Dr. Lee Krug looks at how new approaches in research and treatment might improve outcomes for patients with metastatic mesothelioma. Medscape Hematology-Oncology (Source: Medscape Today Headlines)
Aberrant DNA methylation profile in pleural fluid for differential diagnosis of malignant pleural mesothelioma
SummaryMalignant pleural mesothelioma (MPM) usually develops pleural fluid. We investigated the value of DNA methylation in the pleural fluid for differentiating MPM from lung cancer (LC). Pleural fluid was collected from 39 patients with MPM, 46 with LC, 25 with benign asbestos pleurisy (BAP), and 30 with other causes. The methylation of O6?methylguanine?DNA methyltransferase (MGMT), p16INK4a, ras association domain family 1A (RASSF1A), death?associated protein kinase (DAPK), and retinoic acid receptor ß (RARß) was examined using quantitative real?time PCR. DNA methylation of RASSF1A, p16INK4a, RARß, MGMT, and DAPK was detected in 12 patients (30.8%), 3(7.7%), 11(28.2%), 0(0.0%), and 5(12.8%) with MPM, and in 22 patients (47.8%), 14(30.4%), 24(52.2%), 1(2.2%), and 6(13.0%) with...
High Cost of Asbestos Abatement Derailing Another Historic Renovation
The economy is tough all over, and it is especially tough on cities and counties that find themselves needing to do an asbestos abatement. The cost can be prohibitive, it has altered more than one historic renovation. The latest is in Bartonville, Illinois. (Source: Asbestos and Mesothelioma News)
Diameter and rigidity of multiwalled carbon nanotubes are critical factors in mesothelial injury and carcinogenesis [Medical Sciences]
Multiwalled carbon nanotubes (MWCNTs) have the potential for widespread applications in engineering and materials science. However, because of their needle-like shape and high durability, concerns have been raised that MWCNTs may induce asbestos-like pathogenicity. Although recent studies have demonstrated that MWCNTs induce various types of reactivities, the physicochemical features of MWCNTs that determine their cytotoxicity and carcinogenicity in mesothelial cells remain unclear. Here, we showed that the deleterious effects of nonfunctionalized MWCNTs on human mesothelial cells were associated with their diameter-dependent piercing of the cell membrane. Thin MWCNTs (diameter ? 50 nm) with high crystallinity showed mesothelial cell membrane piercing and cytotoxicity in vitro and subseq...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Please support the <a href="http://www.doctorsinchains.org/" target="_blank">Doctors In Chains</a> campaign for the <a href="http://www.doctorsinchains.org/">medics</a> tortured and sentenced for up to 15 years in <a href="http://www.doctorsinchains.org/">Bahrain</a>. <a href="https://twitter.com/#!/search/%23FreeDoctors">#FreeDoctors</a></p></div>
A Live-attenuated Listeria Vaccine (ANZ-100) and a Live-attenuated Listeria Vaccine Expressing Mesothelin (CRS-207) for Advanced Cancers: Phase 1 Studies of Safety and Immune Induction.
CONCLUSIONS: ANZ-100 and CRS-207 administration was safe and resulted in immune activation. PMID: 22147941 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)
Carbonic anhydrase IX is expressed in mesothelioma and metastatic clear cell renal cell carcinoma of the lung
Abstract&nbsp;&nbsp;High immunohistochemical expression of carbonic anhydrase IX (CAIX) is found in clear cell renal cell carcinoma (ccRCC), but no studies have assessed CAIX in metastatic ccRCC (mccRCC) of the lung. As 75% of patients with mccRCC show lung involvement, characterization of protein expression in these lesions is warranted. This investigation analyzed CAIX immunohistochemical expression in pulmonary/pleural tumors including mccRCC (n?=?22), mesothelioma (n?=?19), squamous cell carcinoma (n?=?27), small cell carcinoma (n?=?9), and adenocarcinoma (n?=?49), as well as other mesothelial lesions (n?=?4). Membranous immunoreactivity was semiquantitatively evaluated for percent of cells stained and intensity. All cases of mccRCC (1+, 4.5%; 3+, 95.5%) and...
Garlock Submits Chapter 11 Exit Plan to Repay 100,000 Asbestos Claims
Garlock Sealing Technologies submitted a Chapter 11 exit plan to the North Carolina bankruptcy judge. The plan will create a trust fund payment for current and future asbestos claimants, which may involve as many as 100,000 claims. The company plans to set aside $60 million with an additional $140 secured by the company's stock. (Source: Asbestos and Mesothelioma News)
ERRATUM for a missing eComment 'Malignant pleural mesothelioma: a therapeutic challenge' [Erratum]
(Source: Interactive CardioVascular and Thoracic Surgery)
Downregulation of MUC1 expression and its recognition by CD8+ T cells on the surface of malignant pleural mesothelioma cells treated with HDACi
This study suggests that the choice of tumor antigens could be critical for strategies combining epigenetic drugs with immunotherapy. (Source: European Journal of Immunology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.januarysales.org/" target="_blank">January Sales</a> in the UK.</p></div>
Week in Review: Canada Asbestos Mines Shut Down, Spirulina Treatment Emerges
It was a week of good news at the Mesothelioma Center. News broke about two asbestos mines in Canada closing and that spirulina, a natural supplement, could help mesothelioma patients. In addition, Hispanic leaders went to the National Press Club in Washington, D.C., and pushed for tougher asbestos regulations. (Source: Asbestos and Mesothelioma News)
Hispanic Workers in Asbestos Industry Face Language Hurdles, Disease Dangers
Hispanic workers expressed concern about asbestos exposure in the construction industry during a November meeting in Washington D.C. Leaders and workers within the construction and asbestos abatement industries spoke at the National Press Club to request stronger asbestos safety regulations. (Source: Asbestos and Mesothelioma News)
For Some, BWH is Home for the Holidays
Sisters Angela and Dina Rezkalla got a little taste of home last week when BWH staff and other organizations provided guests of the Thornton and Naumes Mesothelioma House and the Patrick Thompson Suites with a complete Thanksgiving meal. (Source: BWH News)
Christmas Decorations in the Attic Might Be Sprinkled with Asbestos
Even during the holidays, asbestos can be a danger. The toxic mineral once was sprinkled on trees and ornaments as artificial snow. (Source: Asbestos and Mesothelioma News)
Pulmonary nodules detected by thoracic computed tomography scan after exposure to asbestos: diagnostic significance.
CONCLUSIONS: This study confirms the expected excess prevalence of lung cancer in subjects presenting with pulmonary nodules according to the radiologist's report, and shows the absence of relationship between the presence of nodules and level of cumulative asbestos exposure. Our study therefore offers no argument in favour of specific surveillance modalities based on estimated cumulative asbestos exposure. PMID: 22118184 [PubMed - in process] (Source: Clinical Lung Cancer)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Please support the <a href="http://www.doctorsinchains.org/" target="_blank">Doctors In Chains</a> campaign for the <a href="http://www.doctorsinchains.org/">medics</a> tortured and sentenced for up to 15 years in <a href="http://www.doctorsinchains.org/">Bahrain</a>. <a href="https://twitter.com/#!/search/%23FreeDoctors">#FreeDoctors</a></p></div>
Epididymal germinoma: Reality or myth?
We present a case of a 45-year-old male referred urgently for suspected scrotal mass which on ultrasonography showed a lesion in the left epididymal head (possible granuloma). PMID: 22154173 [PubMed - in process] (Source: Canadian Urological Association Journal)
French Study Shows That Later Asbestos Exposure Lowers Risk of Developing Mesothelioma
A French study shows that later asbestos exposure lowers the risk of developing mesothelioma. Recently published reports show that the risk of developing pleural mesothelioma is lower for individuals exposed after the age of 20. Sample studies of 2,466 male cases were conducted from 1987 to 2006. (Source: Asbestos and Mesothelioma News)
Canada?s Asbestos Mining Comes to a Stop, For Now
For 130 years, asbestos mines operated in Canada. Now, with the close of Jeffrey Mine and Lac d'amiante du Canada, they are all shut down at least temporarily. Critics are hopeful they are shut down for good. Asbestos is a known cause of (Source: Asbestos and Mesothelioma News)
Study: Spirulina, Vitamin C Show Promise To Help Liver Damage from Cisplatin
A recent study published in Food and Function indicates that the all-natural dietary supplement spirulina can help reverse the liver damage caused by cisplatin, which is often a key part of chemotherapy treatment for a href="http://www.asbestos.com/mesothelioma/">mesothelioma patients. The best results came when spirulina was given in combination with vitamen C. (Source: Asbestos and Mesothelioma News)
Processing and analysis of serum antibody binding signals from Printed Glycan Arrays for diagnostic and prognostic applications.
Authors: Vuskovic MI, Xu H, Bovin NV, Pass HI, Huflejt ME Abstract Procedures for data preprocessing, quality control, data analysis, evaluation and visualization of the new high-throughput biomarker platform based on printed glycan arrays (PGA) are presented in this paper. PGAs are similar in concept to DNA arrays but contain deposits of various carbohydrate structures (glycans) instead of spotted DNAs. PGA biomarker discovery for the early detection, diagnosis and prognosis of human malignancies and viral diseases is based on the response of the immune system as measured by the level of binding of anti-glycan antibodies from human serum to the glycans on the array. Procedures related to PGA data processing are herein demonstrated in a pilot study of cases representing 50 sera fro...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.januarysales.org/" target="_blank">January Sales</a> in the UK.</p></div>
National survey of malignant mesothelioma and asbestos exposure in Japan
SummaryWe retrospectively investigated malignant mesothelioma (MM) cases in Japan. We extracted 6,030 cases of death due to MM between 2003 and 2008 to clarify the clinical features of MM including the association with asbestos exposure (AE). Among them, clinical diagnosis of MM was confirmed in 929 cases. The origin of MM included the pleura in 794(85.5%) cases, the peritoneum in 123(13.2%) cases, the pericardium in 7(0.8%) cases, and the testicular tunica vaginalis in 5(0.5%) cases. The histological subtype of MM included 396(55.9%) epithelioid, 154(21.7%) sarcomatoid, 126(17.8%) biphasic, and 33(4.7%) cases classified as other types. AE was indicated in 76.8% and pleural plaques were detected in 34.2% of all MM cases. Asbestos particles were determined in 103 MM cases. More than 1,000 a...
Construction Workers And Electricians At High Risk Of Asbestos Exposure
Asbestos exposure is known to cause : Mesothelioma Lung cancer Asbestosis Statistics show it is particularly prevalent amongst construction workers and electricians due to their constant contact with construction materials and dust, some of which is likely to include asbestos, no matter how careful they are. Asbestos, although a natural fiber, when swallowed or inhaled, can cause grave health risks as fibers trapped in the body begin to cause irritation, tumors and especially pulmonary problems... (Source: Health News from Medical News Today)
Mesothelioma, Erionite Warning Issued by NIOSH
The National Institute for Occupational Safety and Health called for more protective measures on job sites for workers who may be exposed to erionite, a mineral similar to asbestos. NIOSH warned that erionite is America's next mineral danger and is similar to asbestos in the diseases it can cause. (Source: Asbestos and Mesothelioma News)
Family of Mesothelioma Patient Receives Largest Settlement in Missouri History: $10 million
The family of a Nancy Lopez, who died from &#60;a href=&#34;http://www.asbestos.com/mesothelioma/malignant/&#34;mesothelioma cancer, reached a $10 million settlement, the largest in Missouri history for an asbestos case. The value of many asbestos-related settlements are never known. (Source: Asbestos and Mesothelioma News)
Paclitaxel-Loaded Expansile Nanoparticles in a Multimodal Treatment Model of Malignant Mesothelioma [ORIGINAL ARTICLES: GENERAL THORACIC]
Conclusions A murine model of CRS for malignant mesothelioma allows the in vivo assessment of multimodal therapy, including nanoparticle delivery. Combination therapy was superior to no treatment or CRS alone in prolonging survival. Treatment with Pax-eNP improved overall survival in the setting of CRS, suggesting that Pax-eNP merits further evaluation for intracavitary drug delivery following the surgical resection of malignant mesothelioma. (Source: The Annals of Thoracic Surgery)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Please support the <a href="http://www.doctorsinchains.org/" target="_blank">Doctors In Chains</a> campaign for the <a href="http://www.doctorsinchains.org/">medics</a> tortured and sentenced for up to 15 years in <a href="http://www.doctorsinchains.org/">Bahrain</a>. <a href="https://twitter.com/#!/search/%23FreeDoctors">#FreeDoctors</a></p></div>
International Think Tanks Attempt To Shape Asbestos Policy
International think tanks like Cellegium Ramazzini are helping in the fight against asbestos use by pushing for reform in public policy by governments around the world. They are using scientific data to sway policy makers to ban asbestos use to reduce diseases like mesothelioma, which can result from asbestos exposure. (Source: Asbestos and Mesothelioma News)
New York Mesothelioma Attorney Praises FDA?s Efforts To Slash...
Victims of asbestos-related cancer have enough concerns without having to worry about access to anti-mesothelioma drugs, says Joseph W. Belluck of New York?s Belluck & Fox, LLP.(PRWeb November 21, 2011)Read the full story at http://www.prweb.com/releases/ny-mesothelioma-lawyer/mesothelioma-treatment/prweb8982101.htm (Source: PRWeb: Medical Pharmaceuticals)
Asbestos Abatement in Arizona Gymnasium Costs School District $160K in Tight Times
The Payson Unified School District was stunned at the cost, but in the end voted to have asbestos abated from its high school gymnasium. The abatement comes as the district, like many across the country, are dealing with budget cuts. Asbestos is a known cause for mesothelioma, a cancer for which there is no known cure. (Source: Asbestos and Mesothelioma News)
Immunolocalization of nestin, mesothelin and epithelial membrane antigen (EMA) in developing and adult serous membranes and mesotheliomas.
Authors: Petricevic J, Punda H, Brakus SM, Vukojevic K, Govorko DK, Alfirevic D, Kvesic A, Saraga-Babic M Abstract The spatial and temporal distribution of epithelial membrane antigen (EMA), mesothelin and nestin was immunohistochemically analyzed in developing and adult human serous membranes and mesotheliomas in order to detect possible differences in the course of mesenchymal to epithelial transformation, which is associated with differentiation of mesothelial cells during normal development and tumorigenesis. Pleura and pericardium developing from the visceral mesoderm gradually transform into mesothelial cells and connective tissue. EMA appeared in mesothelium of both serous membranes during the early fetal period, whereas during further development, EMA expression was retaine...
Ten-year survival rates of methylprednisolone plus cyclophosphamide followed by mycophenolate mophetyl of azathiopurine for progressive systemic sclerosis patients
Abstract&nbsp;&nbsp;Progressive systemic sclerosis is a multisystem disease characterized by vascular abnormalities, connective tissue sclerosis, atrophy, and the presence of autoantibodies. Up to now, symptomatic therapy was the mainstay, but immunosuppressive therapies have shown encouraging results in the inhibition of the disease progression. Our clinic has been treating these patients with methylprednisolone and cyclophosphamide followed by azathiopurine or mycophenolate mophetyl after 2&nbsp;years (MPC?MMA combination) for nearly 30&nbsp;years, and we wanted to present the treatment results of our patients. Systemic sclerosis patients who have applied to our rheumatology clinic from April 1981 to December 2010 were all treated with MPC?MMA combination therapy. All the data ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.januarysales.org/" target="_blank">January Sales</a> in the UK.</p></div>
Both Good and Bad News in Mesothelioma Research This Week
There was good news and not so good news for mesothelioma research this week. Our weekly news roundup details a breath test that sounds promising for detecting pleural mesothelioma but also a study that shows a drug regimen using thalidomide was not effective in treating mesothelioma. (Source: Asbestos and Mesothelioma News)
Can new ?Electronic Nose? Device Diagnose Mesothelioma by Somone?s Breath? Researchers Say Yes
Can pleural mesothelioma be detected by someone's breath? Dutch and Italian researchers think so, and early test results are promising. (Source: Asbestos and Mesothelioma News)
Australian Experts No Longer Consider Bonded Asbestos To Be Safe
The Asbestos Management Review in Australia decided the country should ban bonded asbestos because of the dangers it presents in natural disasters. Asbestos is a known cause of mesothelioma. (Source: Asbestos and Mesothelioma News)
Researcher: Thalidomide Does Not Slow Malignant Pleural Mesothelioma
Dutch scientist Peter Baas, M.D., said that a recent one-year Phase III clinical trial studying thalidomide did not prove to help pleural mesothelioma patients. Baas gave results of the study at a gathering of cancer researchers in Perth, Australia. (Source: Asbestos and Mesothelioma News)
Adiponectin Pathway Attenuates Malignant Mesothelioma Cell Growth.
Authors: Niu K, Asada M, Okazaki T, Yamanda S, Ebihara T, Guo H, Zhang D, Nagatomi R, Arai H, Kohzuki M, Ebihara S Abstract Malignant mesothelioma (MM) is caused by exposure to asbestos. Because MM has a latency period, short survival time, and has a poor response to current therapeutic regimes, long-term preventive strategies are required to suppress the advance of pathological states after asbestos exposure. Accumulating evidences suggest that adiponectin plays a crucial role in the regulation of energy metabolism by increasing AMP-activated protein kinase (AMPK) activation. Several studies have indicated that the activation of AMPK decreases cyclooxygenase-2 (COX-2) expression. Since high COX-2 levels correlated with a worse prognosis and survival rate in MM, we examined whether...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Please support the <a href="http://www.doctorsinchains.org/" target="_blank">Doctors In Chains</a> campaign for the <a href="http://www.doctorsinchains.org/">medics</a> tortured and sentenced for up to 15 years in <a href="http://www.doctorsinchains.org/">Bahrain</a>. <a href="https://twitter.com/#!/search/%23FreeDoctors">#FreeDoctors</a></p></div>
West Virginia Still Ripe for Asbestos-Related Claims
West Virginia does not have a lot of residents, but it is a Top Five state when it comes to asbestos lawsuits. The American Tort Reform Foundation considers the state one of its top-five "judicial hellholes" for asbestos defendants. (Source: Asbestos and Mesothelioma News)
What Is Mesothelioma? Cancer From Asbestos
Mesothelioma, more precisely known as malignant mesothelioma is a rare cancer of the mesothelial cells, most commonly those in the lining that covers the lungs (pleura). Mesothelial cells exist in the lining (membrane) that covers the outer surface of our body organs. The majority of people with mesothelioma have been exposed to asbestos at some time during their life. Doctors usually divide mesothelioma into three types: Pleural mesothelioma - affects the pleura, the lining surrounding the lungs. This is the most common form... (Source: Health News from Medical News Today)
Transient but Not Stable ZEB1 Knockdown Dramatically Inhibits Growth of Malignant Pleural Mesothelioma Cells
Conclusions&nbsp;&nbsp;RNA interference-mediated ZEB1 knockdown may be a promising therapeutic strategy for MPM, but one has to consider the possibility of diminished growth inhibitory effects of long-term ZEB1 knockdown, possibly as a result of EpCAM up-regulation and/or other gene expression changes resulting from ZEB1 knockdown. Content Type Journal ArticleCategory Translational Research and BiomarkersPages 1-12DOI 10.1245/s10434-011-2142-0Authors Mihoko Horio, Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, JapanMitsuo Sato, Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, JapanYoshihiro Takeyama, Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Jap...
Dominion Virginia Power Disputes Claims of Asbestos Exposure at Power Plant
Dominion Virginia Power is appealing a fine after inspectors found asbestos dust on the clothes of 12 workers at a nuclear power plant. Asbestos is a known cause of mesothelioma cancer. (Source: Asbestos and Mesothelioma News)
Bonded Asbestos No Longer Considered Safe, Say Experts
The rise in the number of natural disaster means we cannot consider bonded asbestos as safe anymore, cancer experts in Perth said in the Clinical Oncological Society of Australia's Annual Scientific Meeting. The increase in the incidence of floods, earthquakes, cyclones and bushfires have put Australians at a significantly higher risk of asbestos-related diseases, according to submissions to the Asbestos Management Review They are referring specifically to materials built from 1945 to 1980 which have been destroyed by natural disaster, releasing harmful fibers into the environment... (Source: Health News from Medical News Today)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.januarysales.org/" target="_blank">January Sales</a> in the UK.</p></div>
Metastases to the oral region from pleural mesothelioma: Clinicopathologic review
ConclusionsThe incidence of mesothelioma is predicted to continue to increase for at least another decade. Clinicians and pathologists should be aware of this lesion and its propensity to metastasize to the oral cavity. © 2011 Wiley Periodicals, Inc. Head Neck, 2011 (Source: Head and Neck)
Immunohistochemical Profile of Paratesticular Serous Papillary Adenocarcinoma and Tunica Vaginalis Facilitates Distinction From Malignant Mesothelioma
This study reports a case of paratesticular serous papillary adenocarcinoma (SPA) in an 87-year-old man that was misdiagnosed as malignant mesothelioma (MM) and is 37 years older than previous cases, highlighting that SPA does not occur exclusively in young patients as described. Immunohistochemistry revealed expression of pankeratin, CAM 5.2, CK7, CK903, Ber-EP4, vimentin, S100, and CEA and virtually no expression of CK5/6, CK20, calretinin, thrombomodulin, or glypican 3. Expression of adjacent nonneoplastic tunica vaginalis mesothelium was assessed in this patient and additional specimens. Profiles of paratesticular SPA and MM were summarized and compared with paratesticular mesothelium. Nontumoral stromal and entrapped mesothelial expression were 2 diagnostic pitfalls in this case that ...
Adjuvant radiotherapy after extrapleural pneumonectomy for mesothelioma. Prospective analysis of a multi-institutional series
Conclusion: Postoperative RT with modern techniques is an effective method to obtain excellent local control and cure rates in mesothelioma patients submitted to EPP. (Source: Radiotherapy and Oncology)
Weekly Mesothelioma and Asbestos News Roundup: Veteran Survivor and National Lung Cancer Awareness Month
This week's asbestos and mesothelioma news roundup includes Frank Curre, a World War II veteran who survived the Pearl Harbor attacks and is now surviving mesothelioma, and news of National Lung Cancer Awareness Month. (Source: Asbestos and Mesothelioma News)
Veterans Day Tribute: Surviving Pearl Harbor and Mesothelioma
Frank Curre survived the Japanese attacks on Pearl Harbor 70 years ago and so far has survived mesothelioma cancer. He said he likely got the cancer from his time in the U.S. Navy. (Source: Asbestos and Mesothelioma News)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Please support the <a href="http://www.doctorsinchains.org/" target="_blank">Doctors In Chains</a> campaign for the <a href="http://www.doctorsinchains.org/">medics</a> tortured and sentenced for up to 15 years in <a href="http://www.doctorsinchains.org/">Bahrain</a>. <a href="https://twitter.com/#!/search/%23FreeDoctors">#FreeDoctors</a></p></div>
Toxicogenomic comparison of multi-wall carbon nanotubes (MWCNTs) and asbestos.
Authors: Kim JS, Song KS, Lee JK, Choi YC, Bang IS, Kang CS, Yu IJ Abstract Carbon nanotubes (CNTs) have specific properties, including electrical and thermal conductivity, great strength, and rigidity, that allow them to be used in many fields. However, this increasing contact with humans and the environment is also raising health and safety concerns. Thus, research on the safety of CNTs has attracted much interest, including a comparison of the toxic effects of asbestos and carbon nanotubes, due to their physical similarity of a high aspect ratio (length/diameter). Nonetheless, there has not yet been a toxicogenomic comparison. Therefore, to examine toxicogenomic effects, the 50% growth inhibition (GI(50)) concentration was determined for multi-wall carbon nanotubes (MWCNTs) and ...
Adjuvant radiotherapy after extrapleural pneumonectomy for mesothelioma. Prospective analysis of a multi-institutional series.
CONCLUSION: Postoperative RT with modern techniques is an effective method to obtain excellent local control and cure rates in mesothelioma patients submitted to EPP. PMID: 22079529 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
November Is Lung Cancer Awareness Month
November is Lung Cancer Awareness Month. Like most mesothelioma cancers, lung cancer hits people where they breathe. (Source: Asbestos and Mesothelioma News)
Mesothelioma Breath Test Hope
Researchers from Italy and The Netherlands have developed an "electronic nose" that appears to be able to tell if someone has Malignant Pleural Mesothelioma (MPM) just from sampling their breath. A report on their study is currently in press but an early issue recently appeared online in the journal Lung Cancer... (Source: Health News from Medical News Today)
Nutritional Stress and Arginine Auxotrophy Confer High Sensitivity to Chloroquine Toxicity in Mesothelioma Cells.
In this study we investigated the effects of CQ on growth, death and autophagic activity of malignant mesothelioma (MM) cell lines cultured in standard versus nutritional stress conditions partially mimicking those found in the tumor microenvironment. We report that in each cell line the toxic effects of CQ were amplified by nutritional stress and paralleled by autophagy inhibition. Still, the cell lines displayed different levels of sensitivity to CQ toxicity which did not correlate with their relative degrees of constitutive and nutritional stress-induced autophagy nor with the relative magnitude of the autophagy inhibition induced by the drug. Thus, we tested the hypothesis that the cell lines' sensitivity to CQ was related to their variable dependence on recycling of intracellular cons...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.januarysales.org/" target="_blank">January Sales</a> in the UK.</p></div>
France To Take More Steps To Protect Workers from Asbestos
Beginning in 2012, the French Ministry for Work, Employment and Health will reduce the permissible levels of asbestos within France. Asbestos is a known cause of mesothelioma cancer.. (Source: Asbestos and Mesothelioma News)
TLE1 is expressed in the majority of primary pleuropulmonary synovial sarcomas
Abstract&nbsp;&nbsp;Pleuropulmonary synovial sarcoma (PPSS) is a rare entity, similar to synovial sarcoma of soft tissue (STSS). There are 120 published cases of PPSS, but no studies have explored the expression of TLE1. In soft tissues, it has been proven a useful marker, but in tumors of other sites, its expression has not been explored. The main objective was to study the expression and diagnostic sensitivity and specificity of TLE1 in a group of PPSS, of which the diagnosis was corroborated by fluorescence in situ hybridization confirming t(X;18) in a tissue microarray. Immunohistochemistry including TLE1, vimentin, CD99, CD56, bcl-2, AE1-AE3, EMA, CD34, CK7, CK19, calponin, and S-100 was performed on all PPSS and on 25 control cases (five carcinomas, ten mesotheliomas, and ten t...
Omaha Police, Wyoming Hospital Are Latest To Deal with Asbestos Abatement
The city of Omaha, Nebraska, and a hospital in Wyoming are the latest public officials to deal with potentially expensive asbestos abatement. Asbestos exposure is a known cause of mesothelioma cancer. (Source: Asbestos and Mesothelioma News)
Prince William and Kate, Royal Family Bring Asbestos Abatement Into Spotlight
Prince William and Kate Middleton, the Duchess of Cambridge, must wait on asbestos abatement of their Kensington Palace home before they move in. The abatement will take a year but will be worth the wait. Asbestos is a known cause of deadly mesothelioma cancer. (Source: Asbestos and Mesothelioma News)
Molecular Pathways: Targeting Mechanisms of Asbestos and Erionite Carcinogenesis in Mesothelioma.
Authors: Carbone M, Yang H Abstract Malignant mesothelioma is an aggressive malignancy related to asbestos and erionite exposure. AP-1 transcriptional activity and NF-kB signaling pathway have been linked to mesothelial cell transformation and tumor progression. HGF and c-Met are highly expressed in mesotheliomas. PI3K, AKT and the downstream mTOR are involved in cell growth and survival and are often found to be activated in mesothelioma. p16INK4a and p14ARF are frequently inactivated in human mesothelioma, and approximately 50% of mesotheliomas contain NF2 mutation. Molecular therapies aimed at interfering with these pathways have not improved the dismal prognosis of mesothelioma, except, possibly, for a small subset of patients that have benefit from certain therapies such as ra...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Please support the <a href="http://www.doctorsinchains.org/" target="_blank">Doctors In Chains</a> campaign for the <a href="http://www.doctorsinchains.org/">medics</a> tortured and sentenced for up to 15 years in <a href="http://www.doctorsinchains.org/">Bahrain</a>. <a href="https://twitter.com/#!/search/%23FreeDoctors">#FreeDoctors</a></p></div>
Executive Order, Genetic Links, New Immunotherapy Make for Busy Week in Mesothelioma, Asbestos World
This week's news roundup from the Mesothelioma Center includes details about President Obama's executive order for drugs, an upcoming symposium at the University of Hawaii organized by Michele Carbone, M.D., and Wake Forest researcher Jill Ohar's research on predisposition for mesothelioma. (Source: Asbestos and Mesothelioma News)
Wake Forest Study Needs Patients To Look Closer at Genetic Link to Mesothelioma
Wake Forest professor Dr. Jill Ohar has studied mesothelioma for two decades, and now she is looking for patients to help with her latest study related to genetic predisposition to mesothelioma cancer. The disease is caused by exposure to asbestos. (Source: Asbestos and Mesothelioma News)
Students Removed from Elementary School Near Chicago after Asbestos Scare
School officials in Carpentersville, Illinois, told parents of elementary students that as many as four classrooms may contain asbestos. Administrators of Sunny Hill Elementary, located approximately 30 miles outside of Chicago, said they promptly removed the elementary students from the tainted classrooms once the issue was identified. Asbestos exposure is known to cause mesothelioma, a rare cancer of the lining of the lungs, lining of the abdomen or lining of the heart. Because of this link from asbestos to this serious disease, school officials left nothing to chance. Barrington Unit District 220 Superintendent Tom Leonard and Sunny Hill Principal Irma Bates sent a letter to parents on November 1to inform parents that all the necessary precautions and safety actions are being taken. The...
Obama?s Executive Order Should Help Mesothelioma Patients Get Chemotherapy
Mesothelioma patients being treated with intravenous chemotherapy likely will be helped in cost and availability by President Barack Obama&#8217;s executive order this week that is designed to ease a growing number of vital-drug shortages. The order not only offers help for drug manufacturers and wholesalers, but it also strengthens efforts by the FDA to prevent and resolve shortages that have cut into the treatment of various cancers, including mesothelioma. There are 84 drugs listed on the FDA&#8217;s latest Current Drug Shortages List, including Cisplatin, which is part of the Standard Care treatment used by oncologists for mesothelioma patients. Alimta (whose generic is pemetrexed), the other most commonly-used chemotherapy drug, is not on the Shortages List, but its high cost (estimat...

shoes along with industrial-grade work gloves for the limbs. The rest of the body should be covered in a proper overall. With all this in place, you’ll now start to understand why your workplace needs to be properly ventilated, not just to minimize the spread of asbestos particles, but also for the sake of personal work comfort which will also influence an individual’s work concentration level when operating a machinery or cutting tool. And at the end of each day before leaving your workplace, ensure that all the PPE listed above is properly stored in a well ventilated designated storage room and your overalls are sent for washing. Needless to say, it would be strongly advisable that you and your staff take a shower before heading out as well. This is in line with the concept of risk reduction. These are just some of the prevention and precautions you can undertake with regards to mesothelioma or asbestos exposure. (Note: readers must be aware that the views expressed above are those of the author and should not be considered as legal advice or grounds to pursue legal judgement. Visit our website to find out more on mesothelioma and asbestos solutions.)